TIMP-2 ELISA Kit, TIMP2 ELISA Kit, Metalloproteinase inhibitor 2 ELISA Kit, Tissue inhibitor of metalloproteinases 2 ELISA Kit
Feiyuebio’s TIMP-2(Tissue Inhibitors of Metalloproteinase 2) ELISA Kit Tissue inhibitor of metalloproteinases 2 (TIMP2) is a gene and a corresponding protein. The gene is a member of the TIMP gene family. The protein is thought to be a metastasis suppressor. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMP), a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.TIMP2 functions as both an MMP inhibitor and an activator. TIMPs inhibit active MMPs, but different TIMPs inhibit different MMPs better than others. For example, TIMP-1 inhibits MMP-7, MMP-9, MMP-1 and MMP-3 better than TIMP-2, and TIMP-2 inhibits MMP-2 more effectively than other TIMPs.In melanocytic cells TIMP2 gene expression may be regulated by MITF.A more recent discovery is that TIMP2 plays an important role in hippocampal function and cognitive function. It plays a critical role in the benefit conferred to old mice when given human umbilical cord blood.
TIMP-2(Tissue Inhibitors of Metalloproteinase 2)This kit uses sandwich ELISA to detect the concentration of TIMP-2(Tissue Inhibitors of Metalloproteinase 2). Standards samples and controls are added to interact with the immobilized antibody. The concentration of TIMP-2(Tissue Inhibitors of Metalloproteinase 2) in the sample can be calculated by comparing the absorbance of the sample with the standard curve.
1, GRCh38: Ensembl release 89: ENSG00000035862 – Ensembl, May 2017
2, Jump up to:a b c GRCm38: Ensembl release 89: ENSMUSG00000017466 – Ensembl, May 2017
3, “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
4, “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
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